Biochemistry I

Paper Code: 
ZOL 114
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Course objectives:

This course will enable the students to –

 

  1. Examine the properties of water, acid-base nature and types of chemical bonds.
  2. Discriminate the structure, classification and cellular metabolic pathways of carbohydrate and lipids.
  3. Judge the principles of bioenergetics and enzyme catalysis along with factors affecting enzyme activity.
  4. Build on their knowledge and understanding about Inborn errors of carbohydrate metabolism, lipid metabolism vitamin deficiency diseases.

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

Paper Code

Paper Title

ZOL 114

Biochemistry I

Students will :

CO 15: Analyze properties of water, acid - base nature, and types of chemical bonds.

CO 16: Formulate structure, classification and cellular metabolic pathways of carbohydrates and lipids.

CO 17: Execute the principles of bioenergetics and enzyme catalysis along with factors affecting enzyme activity.

CO 18: Build on their knowledge which they will implement about Inborn errors of carbohydrate metabolism, lipid metabolism vitamin deficiency diseases.

 

The approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

 

Learning activities for the students:

Self-learning assignments, presentation, Giving tasks,

 

Class test

Semester end examinations,

Quiz,

Assignments,

Presentation

Surprise test

Open book test

 

 

8.00
Unit I: 
UNIT I
Chemistry of biomolecules     
 
  • Water as a solvent, Ionization of water, weak acid and weak bases
  • pH  and buffer
  • Types of chemical bonding:-
  • Electrovalent ,Covalent and non- covalent bond, H-Bond, Van der Waals interaction, Hydrophobic interactions

 

12.00
Unit II: 
UNIT II

Carbohydrates            

●        Classification, Structure & properties (monosaccharides and polysaccharides)

●        Metabolism- Oxidation of glucose through Glycolysis, Krebs cycle, Gluconeogenesis, Pentose phosphate pathway and Oxidative phosphorylation(ETC).

Glycogenesis and Glycogenolysis

10.00
Unit III: 
UNIT III
Lipids   
  • Classification, (Fatty acids, triglycerides, phospholipids, sphingolipids, Gangliosides, Glycolipids.)
  • Structure and  properties
  • Biosynthesis of Triglycerides, Biosynthesis of Palmitic acid
  • Beta-oxidative pathway of fatty acids

 

9.00
Unit IV: 
UNIT IV

Enzymes

 

  • Classification, Properties
  • Mechanism of Enzyme action, activation energy
  • Kinetics (Michaelis-Menton Equation)
  • Factors affecting enzyme action
  • Enzyme Inhibition (Competitive and Non- competitive)
6.00
Unit V: 
UNIT V

Inborn errors of carbohydrate metabolism

  • Inborn errors of carbohydrate metabolism:Galactosemia, Lactose Intolerance, Glycogen storage diseases
  • Inborn errors of lipid metabolism: Niemann pick disease, TaySach’sdisease,Gaucher’s disease, Krabbe’s disease
  • Vitamins: Occurrence, Function, Requirement, Deficiency diseases
Essential Readings: 
  • U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
  • Jain,J.L.Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
  • Murray, R.K.,Harper’sBiochemisttry;Appleton and Lange ,Norwalk,Connecticut.
  • Text  Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.
  • Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
  • Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
  • Widmaier, E.P., Raff, H. and Strang, K.T. (2008)
  • Vander’s Human Physiology, XI Edition., McGraw Hill
  • Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
  • Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
  • Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.
  • Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.
  • LubertStryer, Biochemistry International Student edition W.H. Freeman and Company, New York.
  • Metzler, D. Biochemistry, Academic Press.
  • Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi.
  • Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition. W.H. Freeman and Co.
  • Murray, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2009). Harper’s Illustrated Biochemistry. XXVIII Edition. Lange Medical Books/McGraw Hill.
  • H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.
  • Text Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.

 

Academic Year: 
2021-2022
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