Biochemistry

Paper Code: 
LSC 144 G
Credits: 
04
Contact Hours: 
60.00
Max. Marks: 
100.00
12.00
Unit I: 
CHEMISTRY OF CARBOHYDRATES
Chemistry and classification of carbohydrates.
Monosaccharides disaccharides and oligosaccharides.
Stability and formation of glycosidic bond. Configuration and conformation. Storage and structural polysaccharides and Glycosaminoglycans (heparin, hyaluronic acid) glycoproteins and glycolipids.
12.00
Unit II: 
CARBOHYDRATE METABOLISM
Glycolysis and fermentation, Pasteur, Crabtree and Warburg effects. Reaction of TCA cycle, energy yields and central importance of the cycle. The Cori cycle. Glycogen metabolism and its regulation, Defects in carbohydrate metabolism-Glycogen storage diseases, galactosemia, lactose intolerance.
 
12.00
Unit III: 
LIPID & ITS METABOLISM
Classification of lipids. Chemistry of fatty acids. Bile acids and bile salts. Biological role of neutral fats, phospholipids, cholesterol. Structure and biological role of lipoproteins.
Liposomes.
Fatty acid β-oxidation-. Energy yields from fatty acid oxidation, Control of fatty acid oxidation, Ketogenesis.
Fatty acid biosynthesis, Biosynthesis of triacylglycerols.
Biosynthesis of cholesterol and its regulation. Disorders of lipid metabolism (Ketosis, Niemann Pick disease, Gaucher's
disease, fatty liver, obesity and atherosclerosis).
12.00
Unit IV: 
AMINO ACID, PROTEINS AND METABOLISM
Classification and properties of the amino acids and proteins,Fibrous proteins-keratins, collagen. Globular proteins-myoglobin, hemoglobin. Peptides and the peptide bond,
stability and formation of the peptide bond. Ramachandran plot, levels of protein organization. Protein sequencing.
General reactions in amino acid metabolism. Urea cycle and its regulation. Genetic disorders of amino acid metabolism.
 
12.00
Unit V: 
LIVER AND KIDNEY FUNCTION TESTS
Liver function tests- excretory functions, serum enzymes, metabolic capability and synthetic functions.
Renal function test-glomerular function tests, tubular function tests, serum analysis
Free radicals- types, source and generation of free radicals Anti-oxidants in biological system.
 
Essential Readings: 

Books Recommended:

  • Biochemistry, D.Voet and J.G.Voet, John Wiley & Sons
  • Principles of Biochemistry, Lehninger ,Nelson and Cox
  • Outlines of Biochemistry; Conn, E.E. and Stumpf  P.K. ; John Wiley, New   York.
  • Principles of Biochemistry; Smith; McGraw hill, New York.
  • Biochemistry; Stryer, L; Freeman Publications.
  • Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R.:  Orient Longman, Madras
  • Principles and Techniques in Biochemistry and Molecular Biology, Edited by Keith Wilson and John Walker, Cambridge University Press, (6th Edition), 2007.
  • Biochemistry and Molecular Biology by W.H. Elliot and Daphne C. Elliot, Oxford University Press, (3rd Edition), 2005.Biochemistry, J. David Rawn, Panima Publishing Corporation, 1st Indian Reprint, 2004.
  • Physical Biochemistry, D Friefelder, W.H. Freeman & Company, 17th Reprint, 1999.
  • A Biologist's Guide to Principles and Techniques of Practical Biochemistry, K.Wilson and KH Goulding, ELBS Edition 1986.

 

Academic Year: 
2025-2026
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