BIOCHEMISTRY

Paper Code: 
ZOL-302
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

OBJECTIVES-

To provide students with a basic understanding of:

  1. The chemical nature of biological macromolecules, their three-dimensional construction, and the principles of molecular recognition;
  2. properties of water, acid base nature
  3. different types of chemical bonds  in biomolecules
  4. Structure and classification of carbohydrate and lipids
  5. the metabolism of dietary and endogenous carbohydrate, lipid, and protein; and few Inborn errors related to metabolism.
  6. Sources , functions of Vitamins and their deficiency diseases.

Learning outcomes

By the end of the course, students will be able to:

  1. describe properties of water, acid base nature
  2. describe different types of chemical bonds  in biomolecules
  3. describe Structure and classification of carbohydrate and lipids
  4. demonstrate knowledge and understanding of the principles that govern the structures of macromolecules and their participation in molecular recognition;
  5. describe the principles of bioenergetics and enzyme catalysis;
  6. build on their knowledge and understanding about Inborn errors of carbohydrate metabolism, lipid metabolism and vitamins  deficiency diseases.
14.00
Unit I: 
UNIT I

Carbohydrates

Classification, Properties of Monosacharides,

Metabolism- Glycolysis, Krebs cycle, Gluconeogenesis, Hexose Monophosphate Pathway& Oxidative phosphorylation,Interconversion of glycogen and glucose in liver

8.00
Unit II: 
UNIT II

Lipids

Classification, Metabolism- Biosynthesis of Palmitic acid, Beta-oxidative pathway of fatty acids.

7.00
Unit III: 
UNIT III

Proteins-

 Primary ,Secondary, tertiary and quaternary structure of Proteins,Amino acids-Classification andStructure;Catabolism of amino acids- Oxidative Deamination, Transamination, Decarboxylation, Synthesis of Urea(Ornithine cycle)

8.00
Unit IV: 
UNIT IV

pH and Buffers

Bioenergetics(Thermodynamic laws and ATP);

Vitamins

 Fat soluble & Water soluble vitamins(Source, Function and Deficiency)

8.00
Unit V: 
UNIT V

Enzymes: Classification

Mechanism of Enzyme action, activation energy

Kinetics (Michaelis-Menten Equation)

Factors affecting enzyme action

Enzyme Inhibition

Essential Readings: 
  • U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
  • Jain,J.L.Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
  • Murray, R.K.,Harper’sBiochemisttry;Appleton and Lange ,Norwalk,Connecticut.
  • Text Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.
  • Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
References: 
  • Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
  • Widmaier, E.P., Raff, H. and Strang, K.T. (2008)
  • Vander’s Human Physiology, XI Edition., McGraw Hill
  • Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
  • Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
  • Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.
  • Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.
  • LubertStryer, Biochemistry International Student edition W.H. Freeman and Company, New York.
  • Metzler, D. Biochemistry, Academic Press.
  • Leninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdra, Delhi.
  • Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition. W.H. Freeman and Co.
  • Murray, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2009). Harper’s Illustrated Biochemistry. XXVIII Edition. Lange Medical Books/Mc Graw3Hill.
  • H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.
  • Text Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.


 

Academic Year: 
2019-2020
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