BIOCHEMISTRY

Paper Code: 
ZOL-302
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Course Objectives:

This course will enable the students to

1. To provide students with a basic understanding of chemical nature of biological macromolecules, their three-dimensional construction, and the principles of molecular recognition

2. Learn about different types of chemical bonds in biomolecules and their classification.

3. To understand metabolism of dietary and endogenous carbohydrate, lipid, and protein; and inborn errors related to metabolism.

4. Develop an understanding of sources and functions of vitamins and their deficiency diseases.

Course Outcomes (COs): 

 

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

Paper Code

Paper Title

ZOL302

BIOCHEMISTRY

The students will be able to –

CO30: Describe properties of water, acid base nature, different types of chemical bonds in biomolecules.

CO31: Learn and describe structure and classification of carbohydrate and lipids

CO32: Demonstrate knowledge and understanding of the principles that govern the structures of macromolecules and their participation in molecular recognition

CO33: Understand the principles of bioenergetics and enzyme catalysis.

CO34: Know about in born errors of carbohydrate metabolism, lipid metabolism and vitamins  deficiency diseases.

Approach in teaching:

Interactive class Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

 

Class test

Semester end examinations

Quiz

Assignments

Presentation

Individual and group projects

 

14.00
Unit I: 
UNIT I

Carbohydrates

Classification, Properties of Monosacharides,

Metabolism- Glycolysis, Krebs cycle, Gluconeogenesis, Hexose Monophosphate Pathway& Oxidative phosphorylation,Interconversion of glycogen and glucose in liver

 
8.00
Unit II: 
UNIT II

Lipids

Classification, Metabolism- Biosynthesis of Palmitic acid, Beta-oxidative pathway of fatty acids.

 
7.00
Unit III: 
UNIT III

Proteins-

 Primary ,Secondary, tertiary and quaternary structure of Proteins,Amino acids-Classification andStructure;Catabolism of amino acids- Oxidative Deamination, Transamination, Decarboxylation, Synthesis of Urea(Ornithine cycle)

 
8.00
Unit IV: 
UNIT IV

pH and Buffers

Bioenergetics(Thermodynamic laws and ATP);

Vitamins

 Fat soluble & Water soluble vitamins(Source, Function and Deficiency)

 
8.00
Unit V: 
UNIT V

Enzymes: Classification 

Mechanism of Enzyme action, activation energy

Kinetics (Michaelis-Menten Equation) 

Factors affecting enzyme action

Enzyme Inhibition

 
Essential Readings: 
U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
 
Jain,J.L.Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
 
Murray, R.K.,Harper’s Biochemisttry;Appleton and Lange ,Norwalk,Connecticut.
 
Text Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.
 
Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co. 

 

References: 
Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
 
Widmaier, E.P., Raff, H. and Strang, K.T. (2008) 
 
Vander’s Human Physiology, XI Edition., McGraw Hill
 
Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
 
Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
 
Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York. 
 
Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York. 
 
LubertStryer, Biochemistry International Student edition W.H. Freeman and Company, New York. 
 
Metzler, D. Biochemistry, Academic Press.
 
Leninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdra, Delhi.
 
Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition. W.H. Freeman and Co. 
 
Murray, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2009). Harper’s Illustrated Biochemistry. XXVIII Edition. Lange Medical Books/Mc Graw3Hill.
 
H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut. 
 
Text Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.

 

Academic Year: