BASICS OF NEUROSCIENCE & TOXICOLOGY

Introduction to Neuroscience and Nervous system            

• Neuroscience; Neuroanatomy, Neurophysiology, and Systems Neurobiology  Introduction to the structure and function of the nervous system: Cellular components: Neurons; Neuroglia; Neuron doctrine; 

• Functional architecture of a neuron, 

• Origin and propagation of nerve impulse

Cellular, Molecular Neurobiology and Neurotransmitters

• Molecular and cellular approaches used to study the CNS 

• Synapse:  Types of synapses; synaptic function; 

• Principles of chemical synaptic transmission;

• Different types of neurotransmitters– catecholamines, amino acidergic and peptidergic neurotransmitters;

• Transmitter gated channels; G-protein coupled receptors and effectors, neurotransmitter receptors; Ionotropic and metabotropic receptors.

Neurobiology and Neuropharmacology of Behaviour

• Information processing in the vertebrate central nervous system, 

• Relationship of functional properties of neural systems with perception and behavior

• Sensory systems, molecular basis of behavior including learning and memory.  

• Molecular pathogenesis of pain and neurodegenerative diseases such as Parkinson’s, Alzheimer’s, psychological disorders, addiction, etc. 

 Introduction of  Toxicology           

• History and Scope of Toxicology

• Classification of Toxic Agents : Pesticides and Metals  

• Interaction of Chemicals : Additive,Synergistics, Potentiation, Antagonism

• Dose Response relationship: Acute,Subacute,Subchronic,Chronic

Mechanisms of Toxicity                                                                          

• Delivery and Exposure

• Absorption

• Distribution

• Excretion

• Brief about specific responses of toxicity : Mutagenicity and Teratogenecity