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Advanced Toxicology
Paper Code:
LSC 144 I
Credits:
04
Contact Hours:
60.00
Max. Marks:
100.00
12.00
Unit I:
Principles of Toxicology
- Introduction of toxicology
- Different areas of toxicology
- Toxicology and Society
- General characteristics of the Toxic Response
- Classification of Toxic Agents
- Spectrum of Undesired Effects : Allergic and Idiosyncratic reactions, Immediate versus delayed toxicity. Reversible v/s Irreversible Toxic Effects. Local v/s systemic Toxicity. Interaction of chemicals
- Characteristics of Exposure
- Dose-Response Relationship
- Variation in Toxic Responses
- Descriptive Toxicity Tests
- Toxicogenomics
12.00
Unit II:
Toxic Effects of Metals (I)
- Metal as Toxicants
- Movement of Metals in the Environment
- Mechanism of Metal Toxicity
- Metal-binding Proteins and Metal Transporters
- Pharmacology of Metals
- Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Arsenic and Beryllium
12.00
Unit III:
Toxic Effects of Metals (II)
- Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Cd., Pd, Cu & Fe.
12.00
Unit IV:
Chelation in Metal Intoxication
- Chelating agents, Chemistry, Pharmacology and Toxicology
- Therapy; Combination therapy, Limitations
- Oxidative Stress in Metal Toxicity, Role of antioxidants
- Therapeutic Recommendations for Heavy Metal Poisoning
- Nanotoxicology
- Nanoparticles : Naturally Occurring and Anthropogenic nano-sized material
- Physico-chemical characteristics as Determinants of Biological activity.
- Human Exposure to Nano-sized Materials
- Concept of Noanotoxicology; Ecotoxicological studies, ROS Mechanisms of Nano-sized Pesticide Toxicity, Immunogenicity of nanopesticides.
12.00
Unit V:
Immunotoxicity
- The Immune System; Antigen Recognition
- Innate Immunity, Acquired Immunity
- Inflammation, Immune – Mediated Disease
- Developmental Immunology
- Methods to Assess Immunocompetence
- Immune Modulation by Metals
- Xenobiotic – Induced hypersensitivity and autoimmunity with reference to metals only.
Essential Readings:
Books Recommended:
- Casarett, & Doull’s. (2008). Toxicology: The Basic Science Of Poisons (7th Ed.). New York: Mcgraw-Hill.
- Helferich, W., & Winter, C. K. (2001). Food Toxicology. Crc Press.
- Hodgson, E. (2010). A Textbook Of Modern Toxicology. A John Wiley & Sons, Inc.
- Pandey, K., Shukla, J. P., & Trivedi, S. P. (2011). Fundamentals Of Toxicology. New Central Book Agency.
- Sharma, P. (2005). Environmental Biology And Toxicology. Meerut: Rastogi Publication.
- Shaw, I., & Chadwick, J. ( 1998). Prinicples Of Environmental Toxicology. Taylor & Francis Ltd.
- Wright, D. A., & Welbourn, P. (2002). Environmental Toxicology. New York: Cambridge University Press.
Academic Year:
