Advanced Toxicology

Paper Code: 
LSC 144 I
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
12.00
Unit I: 
UNIT I

Principles of Toxicology

  • Introduction of toxicology
  • Different areas of toxicology
  • Toxicology and Society
  • General characteristics of the Toxic Response
  • Classification of Toxic Agents
  • Spectrum of Undesired Effects : Allergic and Idiosyncratic reactions, Immediate versus delayed toxicity. Reversible v/s Irreversible Toxic Effects. Local v/s systemic Toxicity. Interaction of chemicals
  • Characteristics of Exposure
  • Dose-Response Relationship
  • Variation in Toxic Responses
  • Descriptive Toxicity Tests
  • Toxicogenomics

 

12.00
Unit II: 
UNIT II

Toxic Effects of Metals (I)

  • Metal as Toxicants
  • Movement of Metals in the Environment
  • Mechanism of Metal Toxicity
  • Metal-binding Proteins and Metal Transporters
  • Pharmacology of Metals

Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Arsenic and Beryllium 

12.00
Unit III: 
UNIT III

Toxic Effects of Metals (II)

Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Cd., Pd, Cu & Fe

12.00
Unit IV: 
UNIT IV

Chelation in Metal Intoxication

  • Chelating agents, Chemistry, Pharmacology and Toxicology
  • Therapy; Combination therapy, Limitations
  • Oxidative Stress in Metal Toxicity, Role of antioxidants
  • Therapeutic Recommendations for Heavy Metal Poisoning

Nanotoxicology :

 

  • Nanoparticles : Naturally Occurring and Anthropogenic nano-sized material
  • Physico-chemical characteristics as Determinants of Biological activity.  
  • Human Exposure to Nano-sized Materials

Concept of Noanotoxicology; Ecotoxicological studies, ROS Mechanisms of Nano-sized Pesticide Toxicity, Immunogenicity of nanopesticides. 

12.00
Unit V: 
UNIT V

Immunotoxicity 

·         The Immune System; Antigen Recognition

·         Innate Immunity, Acquired Immunity

·         Inflammation, Immune – Mediated Disease

·         Developmental Immunology

·         Methods to Assess Immunocompetence

·         Immune Modulation by Metals

Xenobiotic – Induced hypersensitivity and autoimmunity with reference to metals only.

Essential Readings: 

·         Casarett, & Doull’s. (2008). Toxicology: The Basic Science Of Poisons (7th Ed.). New York: Mcgraw-Hill.

·         Helferich, W., & Winter, C. K. (2001). Food Toxicology. Crc Press.

·         Hodgson, E. (2010). A Textbook Of Modern Toxicology. A John Wiley & Sons, Inc.

·         Pandey, K., Shukla, J. P., & Trivedi, S. P. (2011). Fundamentals Of Toxicology. New Central Book Agency.

·         Sharma, P. (2005). Environmental Biology And Toxicology. Meerut: Rastogi Publication.

·         Shaw, I., & Chadwick, J. ( 1998). Prinicples Of Environmental Toxicology. Taylor & Francis Ltd.

Wright, D. A., & Welbourn, P. (2002). Environmental Toxicology. New York: Cambridge University Press.

Academic Year: 
2017-2018
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