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Toxicology
Paper Code:
LSC 143 B
Credits:
4
Contact Hours:
60.00
Max. Marks:
100.00
10.00
Unit I:
UNIT I
History and scope of Toxicology
1. Environmental Toxicology
2. Economic Toxicology
3. Forensic Toxicology
Different areas of Toxicology
Classification of Toxic Agents
15.00
Unit II:
UNIT II
Disposition of Toxicants
• Absorption, Distribution & Excretion of Toxicants
Mechanisms of Toxicity
• Delivery
• Absorption
• Distribution
• Excretion
• Cellular Dysfunctions and resultant toxicities
• Repair or Dysrepair
Biotransformation of Xenobiotics
• Phase I Enzymes (Hydrolysis, Reduction, Oxidation
• Phase II Enzyme Reactions (Glucuronidation, Sulfation, Methylation, Acelylation, Amino-acid conjugation Glutathione Conjugation, Phosphorylation )
15.00
Unit III:
UNIT III
Target Organ Toxicity
• Liver
• Blood
Physicochemical nature & Effect of Toxic Agents
• Pesticides
• Metals
• Bioaccumulation and Biomagnification of Toxicants
10.00
Unit IV:
UNIT IV
Non-Organ-Directed Toxicity
• Chemical Carcinogenesis
• Genetic Toxicology
10.00
Unit V:
UNIT V
Environmental Toxicology
• Air Pollution
• Ecotoxicology : Chemodynamics, Biomarkers,
Terrestrial and Aquatic Ecotoxicology
Essential Readings:
Books Recommended:
• Casarett and Daull’s Toxicology: The basic science of poisons. By : Curtis D. Klaassen 6th Edn., McGraw-Hill (Medical Publishing Div. NewYork
• Environmental Biotechnology – by. Indu Shekhar Thakur, I.K. International Pub.(2006)
• Toxicology, Principles and Applications: Raymond I.M.. CRC Publication.
• Microbial Ecology: Fundamentals and Applications by Atlas Bartha (An imprint of Addison Wesley Longman Inc)
• Environmental Microbiology: Maier R.M., Academic Press. 2000 Press, Cambridge. 1993.
• Environmental Science- A global concern; Cunningham W.P. and Saigo B.W Win. C. Brown Publishers, London, 1995.
• Advances in Industrial Waste Water Treatment; P.K. Goel; Technoscience Publications. Jaipur, 1999.
Academic Year:
