Human Genetics- II

Paper Code: 
ZOL 423D
12.00
Unit I: 

Genetic variation – History, Categories of mutations, chromosome and gene mutations, Extrachromosomal mutations, Mutator genes, Mobile genetic elements, Induced mutations, Physical and chemical mutagenes, Molecular basis of spontaneous and induced mutations, DNA repair mechanisms, Reversion, Transposon mutagenesis, In vitro mutagenesis, Environmental mutagenesis Chromosome rearrangements and Cancer. Chromosomal aberration : Numerical : Aneuploidy, Polyploidy Structural : Translocation, Duplication, Inversion, Ring Chromosome and Deletion Others : Mosaic, Chimera [Individual with two cell lines]

12.00
Unit II: 

Immunogenetics - Genetics of normal immune system. Inherited immunodeficiency, eg. X-linked agammaglobulinaemia. Major Histocompatibility Complex – Study of Twins (MHC), HLA disease associations. Tranplantation, graft –versus-host disease. Pharmacogenetic – Definition, gene loci influencing drug metabolism and pharmacogenetic interactions.

12.00
Unit III: 

Extranuclear genetics-Role of organellar genome, maternal inheritance and maternal effect. Stem cell research and cloning Source and isolation of stem cells, Use of stem cells in human welfare, Making stem cell lines :Methodology, Whole body cloning , Organ Cloning

12.00
Unit IV: 

Human Genome Project History, Organization and goals of Human Genome Project Human Genome Project : Friend and Foe ,Repetitive DNA in human genome –Alu and SINE repeats Human genome mapping- Physical, Genetic and Microsatellite mapping,

Unit V: 

Genetic counseling     
Components of genetic counseling, Legal and ethical considerations
risk assessment and counseling in common Mendelian and multifactor syndromes;
Genetic testing: biochemical & molecular tests: in children, Presymptomatic testing for late onset diseases (predictive medicine); Prenatal and Preimplantation screening  and diagnosis: Indications for prenatal diagnosis, Indications for chromosomal testing,
Noninvasive methods (Ultrasound, Embryoscopy, MRI, etc.); Invasive methods; Prenatal screening for Down’s syndrome (maternal  serum) & Neural tube defect; Pre-implantation genetic diagnosis; Ethical issues in pre-natal screening & diagnosis.
Study of Eugenics

  • Negative Eugenics
  • Positive Eugenics
     
References: 
  1. Snustad & Simmons, Principles of Genetics, 4th Edition, Wiley, 2005.
  2.  Hartl and Jones, Genetics-Principles and Analysis, 4th Edition, Jones & Bartlett, 1998.
  3.  Alberts et al, Molecular Biology of The Cell, 2nd Edition , Garland 2007.
  4.  Lewin, Genes IX, 9th Edition , Jones & Bartlett, 2007.
  5. Pastemak, An Introduction to Molecular Human Genetics, 2nd Edition, Fritzgarald, 2005.
  6.  Mange and Mange, Basic Human Genetics, 2nd Edition, Sinauer Assoc, 1999.
  7. Vogel and Motulsky, Human Genetics, 3rd Edition, Springer Verlag, 1997.
  8.  Strachen and Read, Human Molecular Genetics, 3rd Edition, Garland Sci. Publishing, 2004.
  9.  How1ey and Mori, The Human Genome, Academic Press, 1999.
  10. Advanced Molecular Biology Twiman
  11. Molecular Cloning Part- 1 Manniatis
  12. Molecular Cloning Part - 2 Manniatis
  13. Molecular Cloning Part - 3 Manniatis
  14. Structural Chemistry and Molecular Biology Alexander Rich and Norman  Davidson
  15. The Chemical Foundations of Molecular Biology Rebort
  16.  The Chemical Foundations of Molecular James D. Watson
  17. Biology of the Gene (2nd ed.) Molecular Biology of the Cell Lewis and Watson
  18. Recombinant DNA Witkowski
  19. Genes VI Benjamin Lewin
  20.  Principles of gene Manipulation R. W. Old and Primrose
  21.  Progress in Nucleic Acid Research and Molecular Biology Vol. 9 J. N. Davidson
  22.  Essentials of Human Genetics Bhatnagar,Kothari,Mehta
  23. Genes VII Benjamin Lewin
  24. Essentials of Human Genetics by S.M. Bhatnagar etal (1999) IV edition. Orient Longman.
  25. Human Genetics: Concepts and Applications by Lewis R (2001) McGrawHi; Boston.
  26. Basic Human Genetics by E.J. Manage and A.P. Manage (1997 India Reprint) Rastogi Publications, Meerut.
  27. Mendelian inheritance in Man: Catalogs of Autosomal recessive, and x-linked phenotypes.[12th editions –1998 ] byMc Kusick, V.A. Johns Hopkins university press, Baltimore.
     
Academic Year: 
2018-2019
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