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Advanced Toxicology [1]

Paper Code: 
LSC 144 I
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
12.00
Unit I: 
UNIT I
Principles of Toxicology 
• Introduction of toxicology 
• Different areas of toxicology 
• Toxicology and Society 
• General characteristics of the Toxic Response 
• Classification of Toxic Agents
• Spectrum of Undesired Effects : Allergic and Idiosyncratic reactions, Immediate versus delayed toxicity. Reversible v/s Irreversible Toxic Effects. Local v/s systemic Toxicity. Interaction of chemicals
• Characteristics of Exposure 
• Dose-Response Relationship 
• Variation in Toxic Responses 
• Descriptive Toxicity Tests 
• Toxicogenomics 
12.00
Unit II: 
UNIT II
Toxic Effects of Metals (I)
• Metal as Toxicants 
• Movement of Metals in the Environment 
• Mechanism of Metal Toxicity 
• Metal-binding Proteins and Metal Transporters 
• Pharmacology of Metals 
• Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Arsenic and Beryllium 
 
12.00
Unit III: 
UNIT III
Toxic Effects of Metals (II)
• Exposure, Toxicokinetics, Mechanism of Toxicity and Toxicity of Cd., Pd, Cu & Fe
 
12.00
Unit IV: 
UNIT IV
Chelation in Metal Intoxication 
• Chelating agents, Chemistry, Pharmacology and Toxicology
• Therapy; Combination therapy, Limitations 
• Oxidative Stress in Metal Toxicity, Role of antioxidants 
• Therapeutic Recommendations for Heavy Metal Poisoning
Nanotoxicology :
 
• Nanoparticles : Naturally Occurring and Anthropogenic nano-sized material
• Physico-chemical characteristics as Determinants of Biological activity.   
• Human Exposure to Nano-sized Materials 
• Concept of Noanotoxicology; Ecotoxicological studies, ROS Mechanisms of Nano-sized Pesticide Toxicity, Immunogenicity of nanopesticides. 
 
12.00
Unit V: 
UNIT V
Immunotoxicity  
• The Immune System; Antigen Recognition 
• Innate Immunity, Acquired Immunity 
• Inflammation, Immune – Mediated Disease
• Developmental Immunology 
• Methods to Assess Immunocompetence 
• Immune Modulation by Metals 
• Xenobiotic – Induced hypersensitivity and autoimmunity with reference to metals only.
 
Essential Readings: 
Books Recommended:
• Casarett, & Doull’s. (2008). Toxicology: The Basic Science Of Poisons (7th Ed.). New York: Mcgraw-Hill.
• Helferich, W., & Winter, C. K. (2001). Food Toxicology. Crc Press.
• Hodgson, E. (2010). A Textbook Of Modern Toxicology. A John Wiley & Sons, Inc.
• Pandey, K., Shukla, J. P., & Trivedi, S. P. (2011). Fundamentals Of Toxicology. New Central Book Agency.
• Sharma, P. (2005). Environmental Biology And Toxicology. Meerut: Rastogi Publication.
• Shaw, I., & Chadwick, J. ( 1998). Prinicples Of Environmental Toxicology. Taylor & Francis Ltd.
• Wright, D. A., & Welbourn, P. (2002). Environmental Toxicology. New York: Cambridge University Press.
 
Academic Year: 
2021-2022 [2]

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Source URL: https://zoology.iisuniv.ac.in/courses/subjects/advanced-toxicology-5

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[1] https://zoology.iisuniv.ac.in/courses/subjects/advanced-toxicology-5
[2] https://zoology.iisuniv.ac.in/academic-year/2021-2022