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BIOCHEMISTRY (Theory) [1]

Paper Code: 
24ZOL124
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course objectives:

This course will enable the students to –

  1. Enlighten the students about the importance of biological macromolecules, structures and configurational properties.
  2. Examine the key role of biochemistry in the metabolic process.

 

 

Course Outcomes: 

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessmen t Strategies

Course Code

Course Title

24ZOL

124

Biochemis try

(Theory)

CO19:Analyze  the   concepts   of

biocatalysts,  enzyme  activity,  its

kinetics,    inhibition    and    redox

reactions.

CO20:Acquire detailed knowledge

about the

Structure,  classification,  physico-

chemical properties and biological

significance,     metabolism      and

metabolic           disorders           of

carbohydrates.

CO21:Illustrate         the         lipid

classification, structure, properties,

anabolic and catabolic pathways of

lipid    metabolism   and           disorders associated with them.

CO22:Classify proteins and amino

acids based on various parameters.

Compare   and   contrast   between

different     levels      of      protein

organization   and    correlate    the

protein sequencing strategies with

its structures.

CO23:Outline   various   catabolic

reactions associated with amino acid

degradation and correlate the inborn

metabolic    disorders   with    their

defective metabolic enzymes and

their consequences.

CO24:Contribute   effectively   in

course-specific interaction

Approach in

teaching:

Interactive

Lectures,

Discussion,

Tutorials,

Reading

assignments,

Demonstration,

Team teaching

Learning

activities for

the students:

Self-learning

assignments,

Effective questions,

Simulation,

Seminar

presentation,

Giving tasks,

Field

practical

Class test

Semester end

examinations,

Quiz,

Assignments,

Presentation

Individual

and group

projects

 

12.00
Unit I: 
UNIT I
  • Biocatalysis
  • Classification and nomenclature of enzymes
  • Mechanism of enzyme action
  • Enzyme Kinetics
  • Inhibition of enzyme
  • Isoenzymes and coenzymes
  • Energy consideration
  • Biological oxidation and reduction
  • Fundamental reactions of biological oxidation
  • Redox potential and Electron transfer system enzymes

 

14.00
Unit II: 
Unit II
  • Carbohydrates
  • Definition, general properties, classification and configuration of carbohydrates
  • Metabolism
  • Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
  • Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
  • Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.

 

 

14.00
Unit III: 
Unit III
  • Carbohydrates
  • Definition, general properties, classification and configuration of carbohydrates
  • Metabolism
  • Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
  • Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
  • Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.

 

 

12.00
Unit IV: 
Unit IV
  • General properties and classification of proteins
  • Amino acid structure and classification
  • Structure of protein-Primary, Secondary, Tertiary And Quaternary
  • Ramachandran plots
  • Globular and fibrous protein- motif in globular proteins
  • Protein Sequencing

 

10.00
Unit V: 
Unit V
  • Protein metabolism
  • Amino acid degradation: Deamination reaction- Oxidative and non oxidative deamination reaction, Transamination and Trans deamination, Decarboxylation, Ornithine cycle of urea formation, Fate of carbon skeleton of amino acids(Metabolism of individual amino acid excluded)
  • Inborn errors of metabolism: Alkaptonuria, Phenylketonuria, Maple Syrup, Tyrosinemia, Albinism, Urea Disorders.

 

Essential Readings: 
  • U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
  • Jain,J.L. Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
  • Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
  • Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
  • Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi.
  • Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition.W.H. Freeman and Co

 

References: 
SUGGESTED READINGS:
● Harvey, Richard A., Ph. D. (2011). Lippincott's illustrated reviews: Biochemistry. Philadelphia
:Wolters Kluwer Health
● Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
● Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
● Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
● Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.
● Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.
● H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.
 
E-RESOURCES:
● e-PGPATHSHALA-INFLIBNET CENTRE
● Biochemistry- Swayam Prabha-https://dth.ac.in/medical/course.php [4]
 
e-JOURNAL:
● Journal of Biochemistry- ISSN 1756-2651
● Biochemistry- ACS Publication- ISSN 1520-4995
● Journal of Cellular Biochemistry- Wiley online Library- Online ISSN: 1097-4644
 
Academic Year: 
2024-2025 [5]

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Source URL: https://zoology.iisuniv.ac.in/courses/subjects/biochemistry-theory

Links:
[1] https://zoology.iisuniv.ac.in/courses/subjects/biochemistry-theory
[2] https://epgp.inflibnet.ac.in/Home/ViewSubject?catid=MNhNzp1RQlU+6LM40KjY1Q==
[3] https://onlinecourses.nptel.ac.in/noc22_cy06/preview
[4] https://dth.ac.in/medical/course.php
[5] https://zoology.iisuniv.ac.in/academic-year/2024-2025