Cell Biology& Genetics I

Paper Code: 
ZOL-102
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

OBJECTIVES-

  1. To  understand  the  structural  architecture and  functions  of  basic  components  of  prokaryotic  and eukaryotic cells and their organelles
  2. To understand the cell theory
  3. To understand the role of membrane in transport of biomolecules across the cell.
  4. To understand how these cellular components are used to generate and utilize energy in cells
  5. To understand the process of cell division in both somatic and germ cell
  6. To understand Vesicular traffic in the secretory and endocytic pathways (GERL)
  7. Students will able to understand Mendelian inheritance patterns & laws of heredity, Interactions of Genes and their expressions.
  8. Students will able to understand Process of Crossing over and linkage in genes
  9. Students will able to understand What are cytoplasmic inheritance and its importance.

 

LEARNING OUTCOMES- 

  1. Students will understand the structures and purposes of basic components of prokaryotic and eukaryotic cells, especially macromolecules, membranes, and organelles.
  2. Students will able to Describe the function and the composition of the plasma membrane.
  3. Students will able to Explain the principles of the cell theory.
  4. Students will able to Understand the importance of the nucleus and its components.
  5. Students will able to describe how the endoplasmic reticulum and Golgi apparatus interact with one another and know with which other organelles they are associated.
  6. Students will able to understand the process of cell division.
  7. Students will able to understand the patterns of Mendelian inheritance and Interactions of Genes and their expressions.
  8. Students will be able to describe role of crossing over and linkage in heredity

Students will be able to describe cytoplasmic inheritance and its importance.

11.00
Unit I: 
UNIT I

Diversity of Cell Size & shape

Cell theory

Structure of Prokaryotic & Eukaryotic cells

Cell membrane structure and function

Active and Passive transport across membranes

Pinocytosis, Phagocytosis

Endocytosis, Exocytosis
 
12.00
Unit II: 
UNIT II

Cell organelles, their structure, composition & function

  • Endoplasmic reticulum
  • Golgi complex
  • Ribosome : structure & functions
  • Lysosomes: Function & intracellular digestion
  • Mitochondria: Organization &function, and Oxidative phosphorylation
  • Peroxisomes
 

Centrioles & Microtubules: cilia & flagella

8.00
Unit III: 
UNIT III

Nucleus

  • Nucleus structure:  Structure & function of nuclear envelope, nuclear matrix and nucleolus
  •  Cell cycle( S, G1,G2,M phase)
  • Mitosis: Phases & process of mitosis
  • Meiosis: Phases & Process of meiosis
 
8.00
Unit IV: 
UNIT IV

Concepts of Genetics

  • Mendelian inheritance patterns & laws of heredity
  • Co and incomplete dominance
  • Interactions of Genes- Supplementary, Complementary, Duplicate, Epistasis(dominant & recessive)
  • Multiple alleles-Coat colour in rabbit, Human blood group-ABO & Rh
  • Gene expression- Lethal genes, Pleiotropic genes
 

Multiple genes- skin colour in human

6.00
Unit V: 
UNIT V
  • Linkage&construction of linkage maps
  • Crossing over- Mechanism, theories, Cytological detection & significance
  • Cytoplasmic inheritance
 
Essential Readings: 
  • Cell Biology by C.B. Powar; Himalaya Publishing House.
  • Cell and Molecular Biology; Phillip Sheeler   Donald E. Bianchi; John Wiley and Sons.
  • The Cell: A Molecular Approach. Cooper, G. Houseman G.R. SinaeurAssoc, New York.

 

References: 
  • Cell and Molecular Biology; De Robertis and De Robertis; Saunders College.
  • Cell and Molecular Biology; Gerald Karp; John Wiley and Sons,inc
  • Essentials cell Biology II Ed., Bruce Alberts, Julian Lewis, James D.Watson; Garland Publishing.
  • Genetics; Winchester, A.M; Oxford and IBH Publishing Co.
Academic Year: 
2019-2020
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